Is “Sugar-Free” Always Better for Your Heart?
By Nicolas Chronos, MD, FACC, FESC
Lake Country Medical Group & Lake Country Medical Concierge
When you are trying to eat healthier, choosing something labeled “sugar-free” can feel like an easy win. Less sugar should be better for you, right?
The answer depends on what is taking its place.
New research on a sweetener called xylitol raises questions about its possible effects on the heart. It also brings us back to something I strongly believe in: building our meals around the Mediterranean diet.
What Is Xylitol?
Xylitol is a sugar substitute found in some sugar-free gums, candies, baked goods, and toothpaste. It belongs to a group of sweeteners called sugar alcohols.
Our bodies make small amounts of xylitol naturally, and tiny amounts are present in some fruits and vegetables. Much larger amounts can be added to sweetened products. NIH overview
What Did the Study Find?
Research presented at the European Society of Cardiology’s 2026 Congress looked at more than 17,000 people in two long-term studies.
People with the highest xylitol levels in their blood had a higher risk of heart attack, stroke, or death than those with the lowest levels:
- In the Canadian study, the risk was 57% higher over six years.
- In the UK study, the risk was 18% higher over 30 years.
These are relative increases compared with the lower-level groups. They do not mean that 57% of people who use xylitol will have a heart attack. Researchers measured xylitol in the blood, rather than how much people ate. ESC research summary
The study does not prove that eating xylitol caused these problems. Other factors could help explain the connection, including how the body makes and processes xylitol.
Still, the findings deserve attention.
Earlier research published in 2024 also raised concerns. In laboratory experiments and a small study of volunteers, xylitol made the blood cells responsible for clotting more responsive. This offers one possible explanation for the link, although more research is needed. 2024 study
What Should You Do With This Information?
My advice is to take a closer look at the foods you eat regularly. A “sugar-free” label tells you about sugar content. It does not tell you everything about a product’s effect on your health.
Read the ingredient list. If several of your everyday foods contain xylitol, bring that up at your next appointment, especially if you have diabetes or heart disease. We can discuss those choices in the context of your overall health.
And if you noticed toothpaste on the list, there is no need to assume your dental routine is harming your heart. These studies do not establish that brushing with xylitol-containing toothpaste causes cardiovascular problems. The researchers specifically said the earlier findings were not a reason to throw away your toothpaste. NIH explanation
Why I Recommend the Mediterranean Diet
I am a strong advocate of the Mediterranean diet because it gives patients a practical, enjoyable way to eat for better heart health.
It emphasizes vegetables, fruits, beans, whole grains, nuts, olive oil, and fish, while limiting processed meats, sweets, and highly processed foods. Research supports this style of eating for reducing cardiovascular risk. American Heart Association
In everyday life, that can look like:
- Oatmeal with berries and walnuts for breakfast.
- A salad with chickpeas, vegetables, and an olive oil dressing for lunch.
- Grilled fish, roasted vegetables, and brown rice for dinner.
- Fresh fruit or a small handful of unsalted nuts for a snack.
There is plenty of room for flavor, variety, and meals you enjoy. You can start with one meal and build from there.
The goal is to make nourishing foods a regular part of your day. Simply replacing sugar substitutes with more sugar would not move us toward that goal.
Let’s Make Healthy Eating Less Complicated
Health headlines can leave you wondering what you are supposed to eat. My role is to help you understand the research and turn it into choices that work in your daily life.
For now, I encourage you to look beyond the label and focus on your overall eating pattern. A Mediterranean approach offers a well-supported place to start.
At Lake Country Medical Group and Lake Country Medical Concierge, we are here to partner with you in caring for your health. When a headline leaves you worried or unsure, bring it up at your next appointment. We can talk through what the research means for you and help you feel more confident about your choices.
To schedule an appointment, call Lake Country Medical Group at 706-485-4004 or to learn more about Lake Country Medical Concierge call us at 706-309-4965.


Lake Country Medical Group: 706-485-4004